Roles of EphA2 in Development and Disease
The Eph family of receptor tyrosine kinases (RTKs) has been implicated in the regulation of many aspects of mammalian development and disease and this review focuses on the roles of EphA2.
Eph receptor tyrosine kinases and their ligands in neural development
- BiologyCurrent Opinion in Neurobiology
Eph receptors and ephrin ligands: embryogenesis to tumorigenesis
This review will address the recent progress in understanding the function of Eph receptors in normal development and how disregulation of these functions could promote tumorigenesis.
ISOLATION AND CHARACTERISATION OF THE DROSOPHILA DROR2 GENE
Receptor tyrosine kinases ( RTKs) are a family of cell-surface receptors that have an important role in an array of cellular responses including cell migration, proliferation and differentiation (…
Eph-related receptors and their ligands: mediators of contact dependent cell interactions
- BiologyJournal of Molecular Medicine
Functional studies indicate that in a number of tissues the receptors and ligands are expressed in complementary domains and mediate repulsive interactions that restrict cell and axon migration.
Ligand for EPH-related Kinase (LERK) 7 Is the Preferred High Affinity Ligand for the HEK Receptor*
- Biology, ChemistryThe Journal of Biological Chemistry
The results indicate that AL1/LERK7 is the preferred high-affinity ligand for HEK, forming a stable 1:1 complex with a dissociation constant of 12 nm, and indicate that some of the reported LERK-receptor interactions are a consequence of the use of bivalent ligand or receptor constructs and may be functionally irrelevant.
Overexpression of the EphA2 tyrosine kinase in prostate cancer
- BiologyThe Prostate
Tyrosine kinases are frequently overexpressed in metastatic tumor cells and this prompted us to screen for tyrosine Kinases that are overexpression in prostate cancer cells.
Eph receptors and ephrins: effectors of morphogenesis.
The role of Eph and ephrin signalling in the formation of segmented structures, in the control of axon guidance and cell migration and in the development of the vasculature is reviewed.
Eph Receptors and Ephrins
- Biology, ChemistryStem cells
The Eph name is derived from the cell line from which the first member was isolated, erythropoietin-producing human hepatocellular carcinoma line, and the ephrins are an abbreviation for Eph family receptor interacting proteins.
Signal transfer by Eph receptors
- BiologyCell and Tissue Research
Explaining which signaling interactions identified for the Eph receptors have physiological significance, how Eph receptor signaling cascades are propagated, and characterizing the intrinsic signaling properties of the ephrins are all exciting questions currently being investigated.
SHOWING 1-10 OF 37 REFERENCES
A novel putative tyrosine kinase receptor encoded by the eph gene.
The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors, and may define a new class of these molecules.
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified, suggesting that they require direct cell-to-cell contact to activate their receptors.
Molecular characterization of a family of ligands for eph‐related tyrosine kinase receptors.
- BiologyThe EMBO journal
Both elk ligand and B61 mRNAs are inducible by tumour necrosis factor in human umbilical vein endothelial cells and both proteins show promiscuity in binding to the elk and the related hek receptors.
Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.
- BiologyMolecular immunology
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.
The identification and characterization of a novel member of the Eph receptor family is described, which is termed Ehk-3 for Eph Homologous Kinase 3, which displays all the major structural features shared by other members of theEph family, including a cysteine-rich region and tandem fibronectin type-III domains in its extracellular portion.
eph, the largest known family of putative growth factor receptors.
- BiologyBritish Journal of Cancer
The recently discovered family of RTKs termed Eph, which currently consists of seven distinct members, eph, eck, elk, cek5, mek4/cek 4/hek, sek and hek2, all of whose cDNAs have been fully sequenced, appears to be the largest known family ofRTKs.
Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.
- BiologyMolecular and cellular biology
The Elk cytoplasmic domain is able to induce tyrosine phosphorylation and DNA synthesis in response to an extracellular ligand, suggesting that Elk and related polypeptides function as ligand-dependent receptor tyrosines kinases.
B61 is a ligand for the ECK receptor protein-tyrosine kinase
It is reported here that recombinant B61 induces autophosphorylation of ECK in intact cells, consistent with B61 being an authentic ligand for ECK.
Overexpression confers an oncogenic potential upon the eph gene.
It is shown that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repeat)-driven artificial expression of the eph gene to a high level, which supports the alleged contribution of overexpressed receptor tyrosine kinases to cell transformation.
Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.
- BiologyThe Journal of biological chemistry