Cell Signaling by Receptor Tyrosine Kinases

@article{Schlessinger2000CellSB,
  title={Cell Signaling by Receptor Tyrosine Kinases},
  author={Joseph Schlessinger},
  journal={Cell},
  year={2000},
  volume={103},
  pages={211-225}
}
Members of the IR family 550 First Avenue are disulfide linked dimers of two polypeptide chains New York, New York 10016 forming an ␣ 2 ␤ 2 heterodimer (Van-Obberghen, 1994). Insulin binding to the extracellular domain of the IR induces a rearrangement in the quaternary heterotetrameric structure that leads to increased autophosphorylation A large group of genes in all eukaryotes encode for of the cytoplasmic domain. As the active forms of insulin proteins that function as membrane spanning… Expand
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