Cell Signaling by Receptor Tyrosine Kinases

  title={Cell Signaling by Receptor Tyrosine Kinases},
  author={Joseph Schlessinger},

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The epidermal growth factor receptor is a receptor tyrosine kinase that plays a critical role in the pathogenesis of many cancers, and intense investigations of fragments of this receptor have provided a detailed view of its activation mechanism, which is reviewed here.

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The identification of this novel signaling mechanism calls for a critical reevaluation of the mechanisms of action of RTKs and their biological roles.

Ligand-induced ErbB receptor dimerization.

  • M. Lemmon
  • Biology, Chemistry
    Experimental cell research
  • 2009



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