Cell Permeable Exogenous Ceramide Reduces Infarct Size in Spontaneously Hypertensive Rats Supporting In Vitro Studies That Have Implicated Ceramide in Induction of Tolerance to Ischemia

@article{Furuya2001CellPE,
  title={Cell Permeable Exogenous Ceramide Reduces Infarct Size in Spontaneously Hypertensive Rats Supporting In Vitro Studies That Have Implicated Ceramide in Induction of Tolerance to Ischemia},
  author={Kazuhide Furuya and Irene Ginis and Hidetaka Takeda and Yong Chen and John M. Hallenbeck},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2001},
  volume={21},
  pages={226 - 232}
}
Previous work in primary cell culture has shown that TNF-α and ceramide are involved in the signaling that induces tolerance to brain ischemia (Ginis et al., 1999; Liu et al., 2000). To validate the in vitro studies, the authors administered cell permeable analogs of ceramides intracisternally or intravenously to examine their effect on neuroprotection after focal cerebral ischemia. Permanent middle cerebral artery occlusion (MCAO) was performed in spontaneously hypertensive rats. Infarct… CONTINUE READING

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