Cell-Passage Activity Is Required for the Malarial Parasite to Cross the Liver Sinusoidal Cell Layer

@article{Ishino2004CellPassageAI,
  title={Cell-Passage Activity Is Required for the Malarial Parasite to Cross the Liver Sinusoidal Cell Layer},
  author={Tomoko Ishino and Kazuhiko Yano and Yasuo Chinzei and Masao Yuda},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={718 - 722}
}
Liver infection is an obligatory step in malarial transmission, but it remains unclear how the sporozoites gain access to the hepatocytes, which are separated from the circulatory system by the liver sinusoidal cell layer. We found that a novel microneme protein, named sporozoite microneme protein essential for cell traversal (SPECT), is produced by the liver-infective sporozoite of the rodent malaria parasite, Plasmodium berghei. Targeted disruption of the spect gene greatly reduced sporozoite… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

Role of host cell traversal by the malaria sporozoite during liver infection

The Journal of experimental medicine • 2013
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

The Plasmodium sporozoite journey: a rite of passage.

Trends in parasitology • 2003
View 3 Excerpts
Highly Influenced

Invasion of mammalian host cells by Plasmodium sporozoites.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2002
View 5 Excerpts
Highly Influenced

Genome sequence of the human malaria parasite

MJ Gardner, N Hall, E Fung, O White, M Berriman
Plasmodium falciparum. Nature • 2002

Similar Papers

Loading similar papers…