Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

  title={Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis},
  author={Dmitriy Kedrin and J. W. A. van Rheenen and Lorena Hernandez and John S Condeelis and Jeffrey E Segall},
  journal={Journal of Mammary Gland Biology and Neoplasia},
Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be “hijacked” by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of… CONTINUE READING
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