Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.

  title={Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.},
  author={Yang Ming and Yao Xiao and Yuan Tian and Shaobing Zhou},
  journal={Macromolecular bioscience},
  volume={19 4},
Considerable efforts have been devoted to enhancing the cell penetration of nanoparticles by coating cell-penetrating peptides (CPPs) on the surface. However, the internalization mechanism for a CPP at different concentrations varies a lot. It is acknowledged that the mechanism is restricted to endocytic pathway at relatively low concentrations; however, direct translocation becomes dominant at high concentrations. This raises an interesting question on how the surface Tat coating density of… Expand
7 Citations
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  • Y. Tian, Shaobing Zhou
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  • Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
  • 2020
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