Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus.

Abstract

A cell's ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSCs), high-magnitude substrate strain (HMS, ≥2%) effectively suppresses adipogenesis via induction of focal adhesion (FA… (More)
DOI: 10.1002/stem.2004

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Cite this paper

@article{Uzer2015CellMT, title={Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus.}, author={Gunes Uzer and William R. Thompson and Buer Sen and Zhihui Xie and S. S. Yen and Sean J. Miller and Guniz Bas and Maya Styner and Clinton T. Rubin and Stefan Judex and Keith W. T. Burridge and Janet E. Rubin}, journal={Stem cells}, year={2015}, volume={33 6}, pages={2063-76} }