Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex

Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in our understanding of how the cytoplasmic cytoskeleton, nuclear envelope, and nucleoskeleton, which are connected via linker of nucleoskeleton and cytoskeleton (LINC) complexes, are emerging as an integrated dynamic signaling… (More)