Cell Lineage Analysis in Human Brain Using Endogenous Retroelements

  title={Cell Lineage Analysis in Human Brain Using Endogenous Retroelements},
  author={Gilad D. Evrony and Eunjung Lee and Bhaven K. Mehta and Yuval Benjamini and Robert M. Johnson and Xuyu Cai and Lixing Yang and Psalm Haseley and Hillel S. Lehmann and Peter J. Park and Christopher A. Walsh},
Somatic mutations occur during brain development and are increasingly implicated as a cause of neurogenetic disease. However, the patterns in which somatic mutations distribute in the human brain are unknown. We used high-coverage whole-genome sequencing of single neurons from a normal individual to identify spontaneous somatic mutations as clonal marks to track cell lineages in human brain. Somatic mutation analyses in >30 locations throughout the nervous system identified multiple lineages… CONTINUE READING
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