Cell Kinetics of Regenerating Liver After 70% Hepatectomy in Rats - 2-Color Flow Cytometric Analysis

@article{Tamura1992CellK,
  title={ Cell Kinetics of Regenerating Liver After
70% Hepatectomy in Rats - 2-Color Flow
Cytometric Analysis},
  author={Jun Tamura and Junji Tanaka and K Fujita and Masanori Yoshida and Takayuki Kasamatsu and Shigeki Arii and Takayoshi Tobe},
  journal={HPB Surgery},
  year={1992},
  volume={5},
  pages={103 - 115}
}
Two-color flow cytometric (FCM) analysis using anti-bromodeoxyuridine (BrdU) monoclonal antibody (MoAb) was used to investigate the cell kinetics of regenerating liver after 70% partial hepatectomy in rats. Three peaks were seen in DNA histograms of rat hepatocyte nuclei, corresponding to diploid(2c), tetraploid(4c), and octaploid(8c). These proportions changed in the course of regeneration which were clearly demonstrated by DNA histograms using flow cytometry. The proportion of diploid… CONTINUE READING
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