Cell Impermeant-based Low-volume Resuscitation in Hemorrhagic Shock: A Biological Basis for Injury Involving Cell Swelling.


OBJECTIVE To determine the role of cell swelling in severe hemorrhagic shock and resuscitation injury. BACKGROUND Circulatory shock induces the loss of energy-dependent volume control mechanisms. As water enters ischemic cells, they swell, die, and compress nearby vascular structures, which further aggravates ischemia by reducing local microcirculatory… (More)
DOI: 10.1097/SLA.0000000000001049


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