Cell Impermeant-based Low-volume Resuscitation in Hemorrhagic Shock: A Biological Basis for Injury Involving Cell Swelling.

Abstract

OBJECTIVE To determine the role of cell swelling in severe hemorrhagic shock and resuscitation injury. BACKGROUND Circulatory shock induces the loss of energy-dependent volume control mechanisms. As water enters ischemic cells, they swell, die, and compress nearby vascular structures, which further aggravates ischemia by reducing local microcirculatory… (More)
DOI: 10.1097/SLA.0000000000001049

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