- Cell Genes and Diabetes : Quantitative and Qualitative Differences in the Pathophysiology of Hepatic Nuclear Factor-1 and Glucokinase Mutations

@inproceedings{Pearson2001CG,
  title={- Cell Genes and Diabetes : Quantitative and Qualitative Differences in the Pathophysiology of Hepatic Nuclear Factor-1 and Glucokinase Mutations},
  author={Ewan Robert Pearson and Gilberto Velho and Penny Clark and Amanda Stride and Maggie H Shepherd and Timothy M. Frayling and Michael P. Bulman and Sian Ellard and Phillipe Froguel and Andrew T Hattersley},
  year={2001}
}
Mutations in the -cell genes encoding the glycolytic enzyme glucokinase (GCK) and the transcription factor hepatocyte nuclear factor (HNF)-1 are the most common causes of maturity-onset diabetes of the young (MODY). Studying patients with mutations in these genes gives insights into the functions of these two critical -cell genes in humans. We studied 178 U.K. and French MODY family members, including 45 GCK mutation carriers and 40 HNF-1 mutation carriers. Homeostasis model assessment of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect.

The Journal of clinical investigation • 1997
View 5 Excerpts
Highly Influenced

Elevated plasma proinsulin/insulin ratio is a marker of reduced insulin secretory capacity in healthy young men.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1999
View 1 Excerpt

Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • 1999

Specific insulin and proinsulin secretion in glucokinase-deficient individuals.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 1999

Similar Papers

Loading similar papers…