Cell-Free Fetal Nucleic Acid Testing: A Review of the Technology and Its Applications

  title={Cell-Free Fetal Nucleic Acid Testing: A Review of the Technology and Its Applications},
  author={L. Sayres and M. Cho},
  journal={Obstetrical & Gynecological Survey},
  • L. Sayres, M. Cho
  • Published 2011
  • Medicine
  • Obstetrical & Gynecological Survey
  • Cell-free fetal nucleic acids circulating in the blood of pregnant women afford the opportunity for early, noninvasive prenatal genetic testing. The predominance of admixed maternal genetic material in circulation demands innovative means for identification and analysis of cell-free fetal DNA and RNA. Techniques using polymerase chain reaction, mass spectrometry, and sequencing have been developed for the purposes of detecting fetal-specific sequences, such as paternally inherited or de novo… CONTINUE READING
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    Publications referenced by this paper.
    Presence of fetal DNA in maternal plasma and serum
    • 2,287
    • PDF
    Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.
    • 1,505
    • PDF
    Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood
    • 883
    • Highly Influential
    • PDF
    Rapid clearance of fetal DNA from maternal plasma.
    • 917
    Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma
    • 723
    • Highly Influential
    • PDF
    The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis.
    • 237
    • Highly Influential
    • PDF
    Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia.
    • 478
    • Highly Influential
    • PDF
    Size distributions of maternal and fetal DNA in maternal plasma.
    • 474
    • PDF