Cell-Extrinsic Defective Lymphocyte Development in Lmna-/- Mice

  title={Cell-Extrinsic Defective Lymphocyte Development in Lmna-/- Mice},
  author={James Scott Hale and Richard L. Frock and Sara A. Mamman and Pamela J Fink and Brian Kennedy},
  booktitle={PloS one},
BACKGROUND Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies. Lmna(-/-) mice also display smaller spleens and thymuses. In this study, we investigated whether altered lymphoid organ sizes are correlated with specific defects in lymphocyte development… CONTINUE READING


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