Cell Elasticity Determines Macrophage Function

@inproceedings{Patel2012CellED,
  title={Cell Elasticity Determines Macrophage Function},
  author={Naimish R. Patel and Medhavi Bole and Cheng Chen and Charles C. Hardin and Alvin T. Kho and Justin D. Mih and Linhong Deng and James Robert Butler and Daniel J Tschumperlin and Jeffrey J. Fredberg and Ramaswamy Krishnan and Henry Koziel},
  booktitle={PloS one},
  year={2012}
}
Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report that macrophage elasticity is a major determinant of innate macrophage function. Macrophage elasticity is modulated not only by classical biologic activators such as LPS… CONTINUE READING

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