Cell Death and Survival The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF 2-Stabilized Tumors

@inproceedings{Yamamoto2014CellDA,
  title={Cell Death and Survival The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF 2-Stabilized Tumors},
  author={Shinsuke Yamamoto and Jun Inoue and Tatsuyuki Kawano and Ken-ichi Kozaki and Ken Omura and Johji Inazawa},
  year={2014}
}
NF-E2–related factor 2 (NRF2) is a master transcriptional regulator that integrates cellular stress responses and is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1) at the posttranslational level. In human cancers, aberrantly stabilized NRF2, either by mutation of NRF2 or KEAP1, plays a vital role in chemoresistance and tumor cell growth… CONTINUE READING