Cell Death: Molecular insights into execution of necroptosis

  title={Cell Death: Molecular insights into execution of necroptosis},
  author={Paulina J Strzyz},
  journal={Nature Reviews Molecular Cell Biology},
  • P. Strzyz
  • Published 17 February 2016
  • Biology
  • Nature Reviews Molecular Cell Biology
Necroptosis is a form of inducible necrotic cell death that involves cell membrane rupture. MLKL is a major effector protein of necroptosis, but how it mediates this process is poorly understood. Quarato et al. used detailed structural analyses of MLKL to propose a model in which MLKL sequentially engages with the plasma membrane for necroptosis execution. MLKL first oligomerizes through interactions in a region known as the brace. This targets MLKL to the membrane, followed by interaction of… 
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