Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

@article{Griffiths1999CellDC,
  title={Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis},
  author={G. Griffiths and L. Dubrez and C. Morgan and N. Jones and J. Whitehouse and B. Corfe and C. Dive and J. Hickman},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={903 - 914}
}
Investigation of events committing cells to death revealed that a concealed NH2-terminal epitope of the pro-apoptotic protein Bak became exposed in vivo before apoptosis. This occurred after treatment of human Jurkat or CEM-C7A T-lymphoma cells with the mechanistically disparate agents staurosporine, etoposide or dexamethasone. The rapid, up to 10-fold increase in Bak-associated immunofluorescence was measured with epitope-specific monoclonal antibodies using flow cytometry and microscopy. In… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death
Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
Phosphorylation of Bcl-2 Is a Marker of M Phase Events and Not a Determinant of Apoptosis*
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
  • A. Gross, Jennifer Jockel, Michael C. Wei, Stanley J. Korsmeyer
  • Biology, Medicine
  • The EMBO journal
  • 1998
Induction of apoptosis by anti-cancer drugs with disparate modes of action: kinetics of cell death and changes in c-myc expression.
Functional Dissection of the Pro-apoptotic Protein Bik
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.
...
1
2
3
4
5
...