Cell-Cycle Transit in Castration-Resistant Prostate Cancer to S-Phase 1 Definition of a FoxA 1 Cistrome

Abstract

The enhancer pioneer transcription factor FoxA1 is a global mediator of steroid receptor (SR) action in hormone-dependent cancers. In castration-resistant prostate cancer (CRPC), FoxA1 acts as an androgen receptor cofactor to drive G2 to M-phase cell-cycle transit. Here, we describe a mechanistically distinct SRindependent role for FoxA1 in driving G1 to S… (More)

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