Cell Cycle-Driven Heterogeneity: On the Road to Demystifying the Transitions between “Poised” and “Restricted” Pluripotent Cell States

@inproceedings{Singh2015CellCH,
  title={Cell Cycle-Driven Heterogeneity: On the Road to Demystifying the Transitions between “Poised” and “Restricted” Pluripotent Cell States},
  author={Amar M. Singh},
  booktitle={Stem cells international},
  year={2015}
}
Cellular heterogeneity is now considered an inherent property of most stem cell types, including pluripotent stem cells, somatic stem cells, and cancer stem cells, and this heterogeneity can exist at the epigenetic, transcriptional, and posttranscriptional levels. Several studies have indicated that the stochastic activation of signaling networks may promote heterogeneity and further that this heterogeneity may be reduced by their inhibition. But why different cells in the same culture respond… CONTINUE READING
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Computa - tional analysis of cell - to - cell heterogeneity in single - cell RNA - sequencing data reveals hidden subpopulations of cells

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