Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa

Abstract

In metazoa, nuclear pore complexes (NPCs) assemble from disassembled precursors into a reforming nuclear envelope (NE) at the end of mitosis and into growing intact NEs during interphase. Here, we show via RNAi-mediated knockdown that ELYS, a nucleoporin critical for the recruitment of the essential Nup107/160 complex to chromatin, is required for NPC… (More)
DOI: 10.1016/j.cell.2010.04.036

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