Cell Cycle Control of DNA Replication

@article{Stillman1996CellCC,
  title={Cell Cycle Control of DNA Replication},
  author={Bruce W. Stillman},
  journal={Science},
  year={1996},
  volume={274},
  pages={1659 - 1663}
}
The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein… 
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The checkpoint mechanisms that function to preserve the integrity of the genome when the normal course of genome duplication is perturbed by factors that damage the DNA or inhibit DNA synthesis are described.
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This chapter reviews the molecular basis for control of the cell cycle and finds mechanisms are largely conserved in mammalian systems, which are the main focus of this chapter.
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Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression.
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Dynamics of pre-replication complex proteins during the cell division cycle.
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Data is presented demonstrating how the MCM proteins associate with the chromatin during the G1 phase, probably defining pre-RCs and then anticipate replication fork movement in a precisely coordinated manner during the S phase of the cell cycle.
Initiation of eukaryotic DNA replication: regulation and mechanisms.
Initiation of genome replication: assembly and disassembly of replication-competent chromatin.
The cdc18 protein initiates DNA replication in fission yeast.
TLDR
It is proposed that cdc18p is central to the molecular mechanism co-ordinating S phase and M phase in concert with changes in activity of the master cell cycle regulator, the cdc2 protein kinase.
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