Cell Cycle Control of DNA Replication

@article{Stillman1996CellCC,
  title={Cell Cycle Control of DNA Replication},
  author={Bruce W. Stillman},
  journal={Science},
  year={1996},
  volume={274},
  pages={1659 - 1663}
}
The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein… 
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Data is presented demonstrating how the MCM proteins associate with the chromatin during the G1 phase, probably defining pre-RCs and then anticipate replication fork movement in a precisely coordinated manner during the S phase of the cell cycle.
The cdc18 protein initiates DNA replication in fission yeast.
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It is proposed that cdc18p is central to the molecular mechanism co-ordinating S phase and M phase in concert with changes in activity of the master cell cycle regulator, the cdc2 protein kinase.
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