Cell Cycle–related Changes in the Conducting Properties of r-eag K+ Channels

@article{Pardo1998CellCC,
  title={Cell Cycle–related Changes in the Conducting Properties of r-eag K+ Channels },
  author={Luis A Pardo and Andrea Brueggemann and Javier Camacho and Walter Stuehmer},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={143},
  pages={767 - 775}
}
Release from arrest in G2 phase of the cell cycle causes profound changes in rat ether-à-go-go (r-eag) K+ channels heterologously expressed in Xenopus oocytes. The most evident consequence of the onset of maturation is the appearance of rectification in the r-eag current. The trigger for these changes is located downstream of the activation of mitosis-promoting factor (MPF). We demonstrate here that the rectification is due to a voltage-dependent block by intracellular Na+ ions. Manipulation of… CONTINUE READING
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