• DOI:10.1126/SCIENCE.1087641
Corpus ID: 25672278

Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12

@article{Wang2003CellCE,
  title={Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12},
  author={Xiaochen Wang and Y. Wu and V. Fadok and Ming-Chia Lee and Keiko Gengyo-Ando and Li-chun Cheng and D. Ledwich and Pei-Ken Hsu and Jia-Yun Chen and Bin-Kuan Chou and P. Henson and S. Mitani and D. Xue},
  journal={Science},
  year={2003},
  volume={302},
  pages={1563 - 1566}
}

• Xiaochen Wang, Y. Wu, +10 authors D. Xue
• Published 2003
• Biology, Medicine
• Science

During apoptosis, phosphatidylserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and has been suggested to act as an “eat-me” signal to trigger phagocytosis. It is unclear how phagocytes recognize phosphatidylserine. Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis. We report that psr-1, the Caenorhabditis elegans homolog of… Expand

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