Cell Biology of Prions and Prionoids: A Status Report.

  title={Cell Biology of Prions and Prionoids: A Status Report.},
  author={Adriano Aguzzi and Asvin K K Lakkaraju},
  journal={Trends in cell biology},
  volume={26 1},
The coalescence of proteins into highly ordered aggregates is a hallmark of protein misfolding disorders (PMDs), which, when affecting the central nervous system, lead to progressive neurodegeneration. Although the chemical identity and the topology of each culprit protein are unique, the principles governing aggregation and propagation are strikingly stereotypical. It is now clear that such protein aggregates can spread from cell to cell and eventually affect entire organ systems - similarly… CONTINUE READING
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