Cell-Based Immunotherapy With Mesenchymal Stem Cells Cures Bisphosphonate-Related Osteonecrosis of the Jaw–like Disease in Mice

@inproceedings{Kikuiri2010CellBasedIW,
  title={Cell-Based Immunotherapy With Mesenchymal Stem Cells Cures Bisphosphonate-Related Osteonecrosis of the Jaw–like Disease in Mice},
  author={Takashi Kikuiri and Insoo Kim and Takyoshi Yamaza and Kentaro Akiyama and Qunzhou Zhang and Yunsheng Li and Chider Chen and Wanjun Chen and Songlin Wang and Anh D Le and Songtao Shi},
  booktitle={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010}
}
Patients on high-dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology remains unknown, and appropriate therapy is not established. Here we have developed a mouse model of BRONJ-like disease that recapitulates major clinical and radiographic manifestations of the human disease, including characteristic features of an open alveolar socket, exposed necrotic bone or… CONTINUE READING

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