Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

  title={Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis},
  author={Barry M. Gumbiner},

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Mechanism and dynamics of cadherin adhesion.

Force measurements quantified both kinetic and strength differences between different classical cadherins that may underlie cell sorting behavior and showed that differential cadherin-mediated adhesion, rather than exclusive homophilic binding between identical caderins, direct cell segregation and the organization of tissue interfaces during morphogenesis is shown.

Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.

The molecular mechanisms of mechanotransduction in adhesions are highlighted and how adhesion molecules mediate cross talk between cell-ECM and cell-cell adhesion sites are highlighted.

Cell adhesion receptors and cancer

Evidence that Cadherin is important for the posttranslationally functional expression of Connexin has been supported by evidence from developmental biology and cancer cell differentiation studies to suggest that some sort of interrelation feedback control exists between the two signal pathways.

The function and regulation of vinculin in cell-cell adhesions

A short hairpin RNA-based knockdown/substitution system is established that perturbs vinculin preferentially at sites of cell-cell adhesion and the mechanism for this effect is investigated, which describes the first known "vinculin recruited to adherens junctions and cell-matrix adhesions".

Cell adhesion signals regulate the nuclear receptor activity

It is determined that the cell adhesion signaling originated from the tight-junction protein claudin-6, which targets members of the nuclear receptor superfamily, such as retinoic acid receptor γ and estrogen receptor α, thereby regulating expression of the respective target genes.

The role of endothelial cell-to-cell junctions in vascular morphogenesis.

The molecules involved in cell- to-extracellular matrix and cell-to-cell interactions have now been characterized and the intracellular signaling pathways activated by these molecules are, on the contrary, still rather obscure.

Tissue architecture: the ultimate regulator of epithelial function?

The role of cell adhesion in the maintenance of tissue structure is discussed and how tissue structure regulates epithelial function is analyzed.

Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network

Recent data have proposed that association of proteins of the catenin family to MT might be important for linking the MT ends to the F-actin-rich cortex and thus orienting mitotic spindles and the placement of the cytokinetic furrow during cell division.

Cadherins and tissue formation: integrating adhesion and signaling

  • K. VleminckxR. Kemler
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1999
How cadherins, through their effects on cell proliferation, cell death, cell polarization, and differentiation, play a role in the formation of tissues and organs in the developing embryo is discussed.



Inside-out integrin signalling

Signal transduction from the extracellular matrix

There are many compelling examples of control of cell differentiation and gene expression through adhesive interactions with extracellular matrix, including activation of T-lymphocytes through the T-cell antigen receptor is markedly enhanced by integrin-mediated adhesion to fibronectin or laminin.

Integrins and signal transduction pathways: the road taken.

Recent advances in understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors are focused on.

Cadherin cell adhesion receptors as a morphogenetic regulator.

Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

Results suggest that elevated tyrosine phosphorylation of proteins such as beta-catenin and p120 Cas contribute to the altered adherens junctions of ras-transformed epithelia.

Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis.

It is shown that N-cadherin is expressed in a specific spatiotemporal manner in the developing limb bud during chondrogenesis in vivo and in cultured limb mesenchyme in vitro, and functionally required in mediating the cell-cell interactions among mesenchymal cells important for chondrogensesis in micromass culture in vitro and in the intact limb bud in vivo.

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

Results distinguish the regulation of G1 phase MAP kinase activity by soluble mitogens and extracellular matrix from that of G0-synchronized NIH-3T3 cells to fibronectin-coated dishes and implicateMAP kinase in shape-dependent cell cycle progression.

Developmental expression of the syndecans: possible function and regulation.

Mechanisms underlying the differential expression of the syndecans are described, focusing on syndecan-1, which can result from soluble extracellular factor(s) acting at multiple levels of cellular regulation.