Cell–cell interaction networks regulate blood stem and progenitor cell fate

  title={Cell–cell interaction networks regulate blood stem and progenitor cell fate},
  author={Daniel C. Kirouac and Gerard J. Madlambayan and Mei Yu and Edward A. Sykes and Caryn Y Ito and Peter W. Zandstra},
  journal={Molecular Systems Biology},
  pages={293 - 293}
Communication networks between cells and tissues are necessary for homeostasis in multicellular organisms. Intercellular (between cell) communication networks are particularly relevant in stem cell biology, as stem cell fate decisions (self-renewal, proliferation, lineage specification) are tightly regulated based on physiological demand. We have developed a novel mathematical model of blood stem cell development incorporating cell-level kinetic parameters as functions of secreted molecule… CONTINUE READING


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Mathematical Modelling of Cell Proliferation: Stem Cell Regulation in Hemopoiesis

  • HE Wichmann, M Loeffler
  • 1985
Highly Influential
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