Cell‐Surface Carbohydrates in Cell Recognition and Response

  title={Cell‐Surface Carbohydrates in Cell Recognition and Response},
  author={Brian K. Brandley and Ronald L. Schnaar},
  journal={Journal of Leukocyte Biology},
Complex carbohydrates coat the surfaces of cells and have the potential to carry the information necessary for cell–cell recognition. Sugar‐specific receptors (lectins) are also present on cells, and can interact with sugars on apposing cells. This may result in the adhesion of the two cells via carbohydrates and specific cell‐surface receptors. Such carbohydrate‐directed cell adhesion appears to be important in many intercellular activities including infection by bacteria and viruses… 

Carbohydrates as recognition molecules in infection and immunity.

  • D. Weir
  • Biology
    FEMS microbiology immunology
  • 1989
The way in which carbohydrate based recognition has been shown to be involved and may provide the basis for further understanding of the importance of these molecules in host-parasite interaction is emphasized.

Quantitative Micro-Adhesion Assay on Polystyrene Matrices

The interaction of cell surface carbohydrates as carriers of biological information and their complementary carbohydrate binding proteins plays an important role in several cell-cell recognition processes and the expression of lectin receptors on eukaryontic cells is investigated.

Detection of glycidic receptors in microalgae using glycodendrons as probes: a new tool for studies on cell surface interactions

Labeled carbohydrates were proved to be a reliable tool for the study of cell surface composition and could be an alternative tool for taxonomic and physiological studies on microalgae or even on other groups of organisms.

Multiple carbohydrate receptors on lymphocytes revealed by adhesion to immobilized polysaccharides

Phosphomannan polysaccharides and fucoidan, a polymer of fucose 4- sulfate, have been demonstrated to inhibit adhesion of lymphocytes to tissue sections that contain high endothelial venules

Revealing the carbohydrate pattern on a cell surface by super-resolution imaging.

This work employed direct stochastic optical reconstruction microscopy (dSTORM) to visualize the pattern of N-acetylglucosamine on Vero cell membranes at the nanometer level of resolution, and found that N-GlcNAcs exist in irregular clusters on the apical membrane.



Immobilized glycoconjugates for cell recognition studies.

  • R. Schnaar
  • Biology, Chemistry
    Analytical biochemistry
  • 1984

Surface components and cell recognition.

The objective of this study was to establish a baseline level of cell adhesion between EMTs and plasma Membrane Fractions in the Nervous System and to establish an upper bound on the total number of cells that responded to EMT treatment.

Hepatocyte adhesion to immobilized carbohydrates. I. Sugar recognition is followed by energy-dependent strengthening.

Gangliosides support neural retina cell adhesion.

Results imply that ganglioside-directed neural retinal cell adhesion varied with embryonic age, and may play a role in cell-cell recognition in the developing nervous system.

Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation

Using an in vitro assay to measure the adhesive interaction between lymphocytes and postcapillary venules, it is found that L-fucose, D mannose, and the L- fucose-rich, sulfated polysaccharide fucoidin specifically inhibit this binding interaction.

Carbohydrate-specific cell adhesion is mediated by immobilized glycolipids.

Interactions of Animal Viruses with Cell Surface Receptors