Celiprolol and the heart.

@article{Taylor1988CeliprololAT,
  title={Celiprolol and the heart.},
  author={S. H. Taylor},
  journal={The American journal of cardiology},
  year={1988},
  volume={61 5},
  pages={
          34C-40C
        }
}
  • S. Taylor
  • Published 10 February 1988
  • Medicine, Biology
  • The American journal of cardiology
Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: a double-blind comparison with metoprolol.
TLDR
Celiprolol appears to be haemodynamically advantageous compared to metoprolol in patients with coronary artery disease and hypertension.
Pharmacology of celiprolol
TLDR
In the pithed rat, celiprolol's ISA was demonstrated at much lower doses than for pindolol, indicating that celiprool behaves like a partial agonist for beta1-adrenoceptors, whereas the ISA developed by pINDolol was only partially blocked by propranolol.
Celiprolol, a β-Adrenoceptor Antagonist with Vasodilator Effect, Improves Hemodynamic Response to Catecholamine, Spontaneous Locomotor Activity, and Survival in Cardiomyopathic Hamsters with Advanced Heart Failure
TLDR
It is suggested that long-term treatment with celiprolol could improve both survival and the hemodynamic responses to dobutamine, associated with the upregulation of beta-receptors, and increased locomotor activity.
Effect of pretreatment with the selective β1-adrenoceptor antagonist bisoprolol on the subsequent cardiovascular actions and β-adrenoceptor subtype specific occupancy of celiprolol in healthy man
TLDR
The ergometric responses of heart rate (HR) and systolic blood pressure (SBP) after celiprolol were reduced to a similar extent as after bisoprolol, but the cardiovascular function at rest was affected in a different way: there was a rise in HR, clear enhancement of cardiac syStolic performance, and a considerable drop in the estimated total peripheral vascular resistance.
Acute Hemodynamic Effects of &bgr;-Blockers in Patients with Severe Congestive Heart Failure: Comparison of Celiprolol and Esmolol
TLDR
Investigation in patients with severe heart failure of the dose-dependent acute hemodynamic effects of celiprolol versus those of esmolol found that initiation of intravenous-blocker therapy with low doses of a &bgr; 1 -blocker with vasodilating effects may have hemodynamic advantages over conventional &b gr;-blockade.
Celiprolol exerts microvascular dilatation by activation of β2-adrenoceptors
TLDR
It is concluded that celiprolol has a vasodilating effect, that this vasodilation is produced by stimulation of β2-adrenoceptors and that the vasodilant effect is more pronounced in smaller than in larger vessels (G3, G4 vs G1, G2).
Comparison of ketanserin and celiprolol on regression of left ventricular hypertrophy in older hypertensive patients
TLDR
Antihypertensive treatment of older persons with ketanserin or celiprolol achieves regression of LV hypertrophy without associated deleterious effects on LV function.
Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties
AbstractEight hydrochlorides of 3-{2-[(2/4-fluorophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared

References

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Differential actions of atenolol and celiprolol on cardiac performance in ischemic heart disease.
TLDR
These studies demonstrated hemodynamic differences between atenolol and celiprolol, presumably related to the ancillary properties of the latter, and the relevance of such differences to the therapy of patients with coronary artery disease deserves further examination.
Beta-blocking drugs and myocardial function.
  • S. Taylor
  • Medicine, Biology
    Journal of cardiovascular pharmacology
  • 1986
TLDR
Celiprolol is a new dimension in beta-blocking therapy in that it achieves these additional hemodynamic benefits by widespread modulation of sympathoadrenal activity.
Effects of celiprolol on reflex control of the cardiovascular system in essential hypertension.
TLDR
The reflex control of circulation before and during antihypertensive treatment with celiprolol is investigated, which, in addition to its beta-blocking action, has vasodilator properties that may stem from interference with neural cardiovascular control.
Comparative effects of metoprolol and celiprolol on cardiac hemodynamics and left ventricular volume at rest and during exercise‐induced angina
TLDR
The lesser adverse impact of Celiprolol on cardiac function may be attributable to ancillary cardiac stimulatory properties offsetting the cardiac depression after β‐adrenoceptor blockade.
Comparison of the acute hemodynamic effects of intravenous celiprolol and propranolol in patients with suspected coronary disease.
TLDR
Results indicate that celiprolol has an acute hemodynamic profile which differs significantly from that of propranolol.
[Haemodynamic characterization of a new beta-receptor blocker celiprolol (st1396) at rest and during ergometer exercise compared with propranolol (inderal) (author's transl)].
TLDR
Celiprolol is a cardio-selective beta-receptor blocker with pronounced intrinsic sympathomimetic activity that increases the heart rate and cardiac output at rest and probably has only a very slight blocking effect on those, beta1-receptors which mediate a positive inotropic effect.
[Double-blind, placebo-controlled trial of propranolol vs celiprolol in stable effort angina: antianginal efficacy and side effects ].
TLDR
A new cardioselective betablocker, celiprolol in a dosage of 100 mg t.i.d. led to a significant reduction of anginal attacks and of nitroglycerin consumption and a slight but constant decrease of triglycerides, and side effects were minor with both drugs.
Celiprolol in the treatment of hypertension: a comparison with propranolol.
A randomized double-blind study compared the antihypertensive efficacy of single daily oral doses of celiprolol 200 or 400 mg to twice daily doses of propranolol 40 or 80 mg in 58 patients with
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