Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis

@article{Meresse2009CeliacDF,
  title={Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis},
  author={Bertrand Meresse and J. Ripoche and Martine Heyman and Nadine Cerf-Bensussan},
  journal={Mucosal Immunology},
  year={2009},
  volume={2},
  pages={8-23}
}
Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 molecules, the main genetic risk factor for this disease can orchestrate a CD4+ T-cell adaptive immune response against gluten, and discuss recent data which shed light on the innate… Expand
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