Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis

  title={Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis},
  author={B. Meresse and J. Ripoche and M. Heyman and N. Cerf-Bensussan},
  journal={Mucosal Immunology},
  • B. Meresse, J. Ripoche, +1 author N. Cerf-Bensussan
  • Published 2009
  • Medicine, Biology
  • Mucosal Immunology
  • Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 molecules, the main genetic risk factor for this disease can orchestrate a CD4+ T-cell adaptive immune response against gluten, and discuss recent data which shed light on the innate… CONTINUE READING
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