Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study.

@article{Singh2006CelecoxibVN,
  title={Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study.},
  author={Gurkirpal Singh and John G. Fort and Jay L. Goldstein and Roger Abramino Levy and Patrick S Hanrahan and Alfonso E. Bello and Lilia Andrade-Ortega and Carl B Wallemark and Naurang M. Agrawal and Glenn M. Eisen and William F. Stenson and George Triadafilopoulos},
  journal={The American journal of medicine},
  year={2006},
  volume={119 3},
  pages={255-66}
}
PURPOSE To evaluate the efficacy and upper gastrointestinal (UGI) safety of celecoxib, compared with nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), among patients with osteoarthritis. METHODS A total of 13274 osteoarthritis patients from 39 countries were randomly assigned to double-blind treatment with either celecoxib 100 mg twice daily (BID), celecoxib 200 mg BID, or nonselective NSAID therapy (diclofenac 50 mg BID or naproxen 500 mg BID) for 12 weeks. Standard validated… CONTINUE READING