Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison.

@article{Emery1999CelecoxibVD,
  title={Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison.},
  author={P T J Emery and Henning K Zeidler and Tore Kristian Kvien and Mario Guslandi and R B Naudin and H Stead and Kenneth M. Verburg and Peter C. Isakson and Richard C. Hubbard and George S. Geis},
  journal={Lancet},
  year={1999},
  volume={354 9196},
  pages={2106-11}
}
BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX), which leads to suppression of COX-1-mediated production of gastrointestinal-protective prostaglandins. Gastrointestinal injury is a common outcome. We compared the efficacy, safety, and tolerability of long-term therapy with celecoxib, a COX-1 sparing inhibitor of COX-2, with diclofenac, a non-specific COX inhibitor. METHODS 655 patients with adult-onset rheumatoid arthritis of at least 6 months' duration… CONTINUE READING
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