Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells

@article{Tsutsumi2006CelecoxibUE,
  title={Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells},
  author={Shuichi Tsutsumi and Takushi Namba and K Tanaka and Yasuhito Arai and Takeshi Ishihara and Mayuko Aburaya and Shinji Mima and Tatsuya Hoshino and Tohru Mizushima},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={1018-1029}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in cancer cells and this effect is involved in their antitumor activity. We recently demonstrated that NSAIDs upregulate GRP78, an endoplasmic reticulum (ER) chaperone, in gastric mucosal cells in primary culture. In the present study, induction of ER chaperones by NSAIDs and the effect of those chaperones on NSAID-induced apoptosis were examined in human gastric carcinoma cells. Celecoxib, an NSAID, upregulated ER chaperones (GRP78… CONTINUE READING
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