Celecoxib induces regression of putative preneoplastic lesions in rat liver.

@article{ArellanesRobledo2006CelecoxibIR,
  title={Celecoxib induces regression of putative preneoplastic lesions in rat liver.},
  author={Jaime Arellanes-Robledo and Lucrecia M{\'a}rquez-Rosado and Julio Isael P{\'e}rez-Carre{\'o}n and Samia Fattel-Fazenda and Jes{\'u}s Aguirre-Garc{\'i}a and Sa{\'u}l Villa-Trevi{\~n}o},
  journal={Anticancer research},
  year={2006},
  volume={26 2A},
  pages={
          1271-80
        }
}
BACKGROUND Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, may reduce the risk and mortality of certain types of human cancer. The chemopreventive effect of celecoxib on preneoplastic lesions induced by chemical hepatocarcinogenesis was investigated. MATERIALS AND METHODS Male Sprague Dawley rats were fed a celecoxib-supplemented diet between days 18 and 26 post-initiation (1500 ppm) and sacrificed on day 26. The effects of celecoxib on proliferation, apoptosis, COX-2 activity and liver… CONTINUE READING

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