Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials.

@article{Macas2010CelecoxibBC,
  title={Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials.},
  author={Alvaro Mac{\'i}as and Cristina Moreno and Javier Moral-Sanz and Angel Cogolludo and Massimiliano David and Matteo Alemanni and Francisco Perez-Vizcaino and Antonio Zaza and Carmen Valenzuela and Ma. Teresa Rodr{\'i}guez Gonz{\'a}lez},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={49 6},
  pages={
          984-92
        }
}
Celecoxib is a COX-2 inhibitor that has been related to an increased cardiovascular risk and that exerts several actions on different targets. The aim of this study was to analyze the effects of this drug on human cardiac voltage-gated potassium channels (Kv) involved on cardiac repolarization Kv1.5 (I(Kur)), Kv4.3+KChIP2 (I(to1)) and Kv7.1+KCNE1 (I(Ks)) and to compare with another COX-2 inhibitor, rofecoxib. Currents were recorded in transfected mammalian cells by whole-cell patch-clamp… CONTINUE READING
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