Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.

@article{Fischer2003CelecoxibAD,
  title={Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.},
  author={Susan M. Fischer and Claudio J. Conti and Jaye Viner and C. Marcelo Aldaz and Ronald A. Lubet},
  journal={Carcinogenesis},
  year={2003},
  volume={24 5},
  pages={945-52}
}
The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when administered throughout the course of UV irradiation. This raised the question of whether maintenance or continued growth of existing tumors required prostaglandins, the product of COX, or polyamines, the product of ODC. To address this question, SKH hairless mice were irradiated 3 times/week with 90 mJ… CONTINUE READING

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