Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection

@inproceedings{Pereira2013CelecoxibIH,
  title={Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection},
  author={Priscilla Aparecida T{\'a}rtari Pereira and Bruno Caetano Trindade and Adriana Secatto and Roberto Nicolete and Camila Peres-Buzalaf and Simone Gusm{\~a}o Ramos and Ruxana T. Sadikot and Claudia da Silva Bitencourt and L{\'u}cia Helena Faccioli},
  booktitle={Mediators of inflammation},
  year={2013}
}
Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses. Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum infection in C57BL/6 mice. Our results showed that treatment with celecoxib inhibited cyclooxygenase 2, reduced the total fungal burden, and reduced the concentration of PGE2, cytokines, lymphocytes… CONTINUE READING
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