Celecoxib: a specific COX-2 inhibitor with anticancer properties.

  title={Celecoxib: a specific COX-2 inhibitor with anticancer properties.},
  author={Alane T. Koki and Jaime L. Masferrer},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  volume={9 2 Suppl},
In addition to the well-established pathophysiological role that COX-2 plays in inflammation, recent evidence implies that this isoform may also be involved in multiple biologic events throughout the tumorigenic process. Many epidemiological studies demonstrate that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of a wide range of tumors. Further, COX-2 is chronically overexpressed in many premalignant, malignant, and metastatic human cancers, and levels of overexpression have… CONTINUE READING