Celastrol suppresses morphological and transcriptional responses in microglial cells upon stimulation with double-stranded RNA.

Abstract

Despite the pivotal role of microglia in the immune system of the brain, a growing body of evidence suggests that excessive microglial activation provokes neuronal and glial damage, leading to neurodegenerative and neuroinflammatory disorders. Celastrol, a triterpene, is a potent anti-inflammatory and antioxidant compound derived from perennial creeping… (More)
DOI: 10.3109/00207451003615763

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.