Celastrol suppresses morphological and transcriptional responses in microglial cells upon stimulation with double-stranded RNA.


Despite the pivotal role of microglia in the immune system of the brain, a growing body of evidence suggests that excessive microglial activation provokes neuronal and glial damage, leading to neurodegenerative and neuroinflammatory disorders. Celastrol, a triterpene, is a potent anti-inflammatory and antioxidant compound derived from perennial creeping… (More)
DOI: 10.3109/00207451003615763


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