Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells.

@article{Paimela2011CelastrolRI,
  title={Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells.},
  author={Tuomas Paimela and Juha M T Hyttinen and Johanna Viiri and Tuomas Ryh{\"a}nen and Reijo O. Karjalainen and Antero Salminen and Kai Kaarniranta},
  journal={Pharmacological research},
  year={2011},
  volume={64 5},
  pages={501-8}
}
Elevated nuclear factor kappa B (NF-κB) activity and interleukin-6 (IL-6) secretion participates in the pathology of several age and inflammatory-related diseases, including age-related macular degeneration (AMD), in which retinal pigment epithelial cells are the key target. Recent findings reveal that heat shock protein 70 (Hsp70) may affect regulation of NF-κB. In the current study, effects of Hsp70 expression on NF-κB RelA/p65 activity were evaluated in human retinal pigment epithelial cells… CONTINUE READING
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