Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents

Abstract

The Fanconi anemia (FA) pathway plays a key role in interstrand crosslink (ICL) repair and maintenance of the genomic stability, while inhibition of this pathway may sensitize cancer cells to DNA ICL agents and ionizing radiation (IR). The active FA core complex acts as an E3 ligase to monoubiquitinate FANCD2, which is a functional readout of an activated… (More)
DOI: 10.1111/cas.12679

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@inproceedings{Wang2015CelastrolIP, title={Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents}, author={Gui-zhen Wang and Yong-qiang Liu and Xin Cheng and Guang-Biao Zhou}, booktitle={Cancer science}, year={2015} }