Celastrol enhances cell viability and inhibits amyloid-β production induced by lipopolysaccharide in vitro.

Abstract

BACKGROUND Neuroinflammation is a notable hallmark of Alzheimer's disease pathogenesis and can markedly exacerbate amyloid pathology. Celastrol, a pentacyclic-triterpene, has been found to possess anti-inflammatory properties. OBJECTIVE The purpose of this study was to characterize the effects of celastrol on cell viability and amyloid-β (Aβ) peptide… (More)
DOI: 10.3233/JAD-131799

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