Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

Lian-jie Lin, Yan Sun, Dongxu Wang, Shihang Zheng, Jing Zhang, Changqing Zheng
Published 2015 in Front. Pharmacol.

Abstract

Celastrol, also named as tripterine, is a pharmacologically active ingredient extracted from the root of traditional Chinese herb Tripterygium wilfordii Hook F with potent anti-inflammatory and anti-tumor activities. In the present study, we investigated the effects of celastrol on ulcerative colitis-related colorectal cancer (UC-CRC) as well as CRC in vivo… (More)

DOI: 10.3389/fphar.2015.00320

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European journal of medicinal chemistry
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References

Sort by:

Showing 1-10 of 22 references

P. Yang, Z. Li, R. Fu, H. Wu
2014

M. E, S. A. Ashamallah, M. E. Houssen
Int. J. Mol. Cell Med
2014

Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis.

K M Sakthivel, C Guruvayoorappan
International immunopharmacology
2013

H. 108000313020701329914 Kang, M. Lee, S. W. Jang
2013

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

Kwong-Fai Wong, Yi Yuan, John M Luk
Clinical and experimental pharmacology…
2012

F. Fan, S. Samuel, K. W. Evans, J. Lu, L. Xia, Y Zhou
Gut
2012

Genetics and pathogenesis of inflammatory bowel disease.

Bernard Khor, Agnès Gardet, Ramnik J Xavier
Nature
2011

M. K. Shanmugam, G. Sethi
2011

A. Y. Sklyarov, N. B. Panasyuk, I. S. Fomenko
between life and death. Oncogene
2011

P. Ge, X. Ji, Y. Ding, X. Wang, S. Fu, F Meng
Cancer Cell
2010

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

Abstract

Topics

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Statistics

Citation Velocity: 22

Cited By

Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation.

Recent progress on the effects of microRNAs and natural products on tumor epithelial–mesenchymal transition

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

References

Pyruvate kinase

compared with selected odontogenic cysts

Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis.

Celastrol inhibits TGF-beta1

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

ulcerative colitis: a meta-analysis

Genetics and pathogenesis of inflammatory bowel disease.

Molecular targets

Role of nitric

dendritic cells

Slides referencing similar topics

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

Abstract

Topics

Figures and Tables

Statistics

Citation Velocity: 22

Cited By

Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation.

Recent progress on the effects of microRNAs and natural products on tumor epithelial–mesenchymal transition

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

References

Pyruvate kinase

compared with selected odontogenic cysts

Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis.

Celastrol inhibits TGF-beta1

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

ulcerative colitis: a meta-analysis

Genetics and pathogenesis of inflammatory bowel disease.

Molecular targets

Role of nitric

dendritic cells

Similar Papers

Slides referencing similar topics