Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat.

@article{Goodrich2013CeftriaxoneTA,
  title={Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat.},
  author={Grant S Goodrich and Anatoli Y. Kabakov and Mustafa Q Hameed and Sameer C. Dhamne and Paul B Rosenberg and Alexander Rotenberg},
  journal={Journal of neurotrauma},
  year={2013},
  volume={30 16},
  pages={1434-41}
}
Excessive extracellular glutamate after traumatic brain injury (TBI) contributes to excitotoxic cell death and likely to post-traumatic epilepsy. Glutamate transport is the only known mechanism of extracellular glutamate clearance, and glutamate transporter 1 (GLT-1) is the major glutamate transporter of the mammalian brain. We tested, by immunoblot, in the rat lateral fluid percussion injury TBI model whether GLT-1 expression is depressed in the cortex after TBI, and whether GLT-1 expression… CONTINUE READING
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