Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study

@article{Nathan2005CeftriaxoneAE,
  title={Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study},
  author={N. Nathan and Timothy Borel and Ali Djibo and D Gareth Evans and Saacou Djibo and JF Corty and Martine Guillerm and KP Alberti and Loretxu Pinoges and P. Gu{\'e}rin and Dominique N. Legros},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={308-313}
}
BACKGROUND In sub-Saharan Africa in the 1990s, more than 600,000 people had epidemic meningococcal meningitis, of whom 10% died. The current recommended treatment by WHO is short-course long-acting oily chloramphenicol. Continuation of the production of this drug is uncertain, so simple alternatives need to be found. We assessed whether the efficacy of single-dose treatment of ceftriaxone was non-inferior to that of oily chloramphenicol for epidemic meningococcal meningitis. METHODS In 2003… Expand
5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study
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The available randomized controlled trial evidence suggests that third generation cephalosporins are as effective as standard treatment regimens that include chloramphenicol for the treatment ofExpand
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References

SHOWING 1-10 OF 38 REFERENCES
Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis
TLDR
It is suggested that long-acting chloramphenicol is a useful first-line presumptive treatment for BM in high-incidence countries. Expand
Chloramphenicol or ceftriaxone, or both, as treatment for meningitis in developing countries?
TLDR
Using a third generation cephalosporin as first line treatment is effective in dealing with the problem of poor outcomes from meningitis due to Haemophilus influenzae that is resistant to chloramphenicol, and a strategy of changing to chlorampshenicol if in vitro susceptibility is shown will reduce the use of expensive thirdgeneration cep Halosporins without comprising on clinical outcomes. Expand
Treatment of childhood bacterial meningitis with ceftriaxone once daily: open, prospective, randomized, comparative study of short-course versus standard-length therapy.
TLDR
The results of the study indicate that the short-duration regimen was adequate for the treatment of meningitis caused by the three major meningeal pathogens, but the small number of patients do not justify the adoption of theshort-course regimen for all children withMeningitis. Expand
A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis.
TLDR
Results of this preliminary study show that a single dose injection of a long-acting chloramphenicol is of value in the management of epidemics of meningococcal meningitis in rural areas because patients can be treated locally and early in their village dispensaries, thereby minimizing the need to transport them to urban hospitals which are often distant and congested. Expand
Long-acting chloramphenicol for bacterial meningitis.
  • Medicine
  • Bulletin of the World Health Organization
  • 1993
TLDR
A controlled clinical trial was carried out to compare the efficacy at day 4 of a double intramuscular injection of long-acting chloramphenicol 100 mg/kg with that of ampicillin administered intravenously for 8 days at 200mg/kg (4 times a day). Expand
Short course single daily ceftriaxone monotherapy for acute bacterial meningitis in children: Results of a Swiss multicenter study. Part I: Clinical results
TLDR
It is suggested that short course treatment of acute bacterial meningitis in children with single daily ceftriaxone monotherapy is as efficacious as full course therapy and at least as well tolerated. Expand
Prospective Comparison of Ceftriaxone and Cefotaxime for the Short-Term Treatment of Bacterial Meningitis in Children
TLDR
Ceftriaxone offers an advantage in ease of administration since it is administered as a single daily dose, and cefotaxime is both effective in the treatment of bacterial meningitis. Expand
Short course single daily ceftriaxone monotherapy for acute bacterial meningitis in children: Results of a Swiss multicenter study. Part II: Bacteriological results
TLDR
The bactericidal power of Ceftriaxone at six times the MIC was as good or better than that of ampicillin alone or in combination againstNeisseria meningitidis andStreptococcus pneumoniae despite the very low drug concentrations of ceftrixone compared to that of the competitors. Expand
Ceftriaxone versus penicillin G in the short-term treatment of meningococcal meningitis in adults
TLDR
It is concluded that short-term treatment with ceftriaxone is feasible but patients with severe forms of meningitis would not be eligible for treatment with this regimen, and careful follow-up of the patients receiving cefticillin G is necessary. Expand
A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children.
TLDR
It is concluded that ceftriaxone is superior to cefuroxime for the treatment of acute bacterial meningitis in children and that the benefits of milder hearing impairment and more rapid sterilization of the cerebrospinal fluid with ceftRIaxone outweigh the problem of reversible biliary pseudolithiasis with this drug. Expand
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