Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

@article{Zumkehr2015CeftriaxoneAT,
  title={Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease},
  author={Joannee Zumkehr and Carlos J. Rodriguez-Ortiz and David Chee-mun Cheng and Zanett Kieu and Masashi Kitazawa},
  journal={Neurobiology of Aging},
  year={2015},
  volume={36},
  pages={2260-2271}
}
Glial glutamate transporter, GLT-1, is the major Na(+)-driven glutamate transporter to control glutamate levels in synapses and prevent glutamate-induced excitotoxicity implicated in neurodegenerative disorders including Alzheimer's disease (AD). Significant functional loss of GLT-1 has been reported to correlate well with synaptic degeneration and severity of cognitive impairment among AD patients, yet the underlying molecular mechanism and its pathological consequence in AD are not well… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Astrocytic transporters in Alzheimer's disease.

  • The Biochemical journal
  • 2017
VIEW 3 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Glial Control of Synapse Number in Healthy and Diseased Brain

  • Front. Cell. Neurosci.
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

L. Zhao, Ma, +8 authors J. E. Hansen
  • Nat. Neurosci
  • 2006
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Animal models of Alzheimer’s disease and frontotemporal dementia

J. Götz, L. M. Ittner
  • Nat. Rev. Neurosci
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The role of synaptic proteins in Alzheimer's disease.

  • Annals of the New York Academy of Sciences
  • 2000
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease

Sze, C.-I, +4 authors L. J. Martin
  • J. Neuropathol. Exp. Neurol
  • 1997
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL