Ceftolozane/Tazobactam Plus Metronidazole for Complicated Intra-abdominal Infections in an Era of Multidrug Resistance: Results From a Randomized, Double-Blind, Phase 3 Trial (ASPECT-cIAI)

@inproceedings{Solomkin2015CeftolozaneTazobactamPM,
  title={Ceftolozane/Tazobactam Plus Metronidazole for Complicated Intra-abdominal Infections in an Era of Multidrug Resistance: Results From a Randomized, Double-Blind, Phase 3 Trial (ASPECT-cIAI)},
  author={Joseph S. Solomkin and Ellie Hershberger and Benjamin Miller and Myra W. Popejoy and Ian Friedland and Judith N. Steenbergen and Minjung Yoon and Sylva H Collins and Guojun Yuan and Philip S. Barie and Christian Eckmann},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2015}
}
BACKGROUND Increasing antimicrobial resistance among pathogens causing complicated intra-abdominal infections (cIAIs) supports the development of new antimicrobials. Ceftolozane/tazobactam, a novel antimicrobial therapy, is active against multidrug-resistant Pseudomonas aeruginosa and most extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. METHODS ASPECT-cIAI (Assessment of the Safety Profile and Efficacy of Ceftolozane/Tazobactam in Complicated Intra-abdominal Infections) was… CONTINUE READING
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