Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli

@article{Zhanel2013CeftolozaneTazobactamAN,
  title={Ceftolozane/Tazobactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli},
  author={G. Zhanel and Phillip Chung and H. Adam and S. Zelenitsky and A. Denisuik and F. Schweizer and P. Lagac{\'e}-Wiens and E. Rubinstein and A. Gin and A. Walkty and D. Hoban and J. Lynch and J. Karlowsky},
  journal={Drugs},
  year={2013},
  volume={74},
  pages={31-51}
}
Ceftolozane is a novel cephalosporin currently being developed with the β-lactamase inhibitor tazobactam for the treatment of complicated urinary tract infections (cUTIs), complicated intra-abdominal infections (cIAIs), and ventilator-associated bacterial pneumonia (VABP. [...] Key Result Ceftolozane demonstrates linear pharmacokinetics unaffected by the coadministration of tazobactam; specifically, it follows a two-compartmental model with linear elimination.Expand
196 Citations
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