Ceftobiprole: a new broad spectrum cephalosporin.

  title={Ceftobiprole: a new broad spectrum cephalosporin.},
  author={Ali A El Solh},
  journal={Expert opinion on pharmacotherapy},
  volume={10 10},
Ceftobiprole, formerly designated BAL9141/Ro 63-9141, is a pyrrolidinone-3-ylidene-methyl cephalosporin with demonstrated in vitro activity against MRSA, Enterococcus faecalis, Enterobacteriaceae and Pseudomonas aeruginosa. Ceftobiprole has a low potential for inducing chromosomal AmpC beta-lactamases but it is hydrolyzed by most extended spectrum beta-lactamases and metallo-beta-lactamases. Glomerular filtration is predominantly responsible for removal of the free drug from the systemic… CONTINUE READING